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Pfizer: Pfizer's 2025 Earnings: A Strong Performance

Pfizer reported a robust financial performance for 2025, with revenues of $62.6 billion and operational revenue growth of 6% when excluding COVID-19 products. The company's adjusted diluted EPS was $3.22, ahead of expectations. In the fourth quarter, revenues were $17.6 billion, with non-COVID product performance growing 9% operationally versus the same period last year. Adjusted gross margin for the quarter was approximately 71%, reflecting a strong product mix and cost management. The company's reported diluted GAAP performance was a loss per share of 29ยข, while adjusted diluted earnings per share was $0.66, beating estimates of $0.567.

PFE

USD 27.73

0.43%

A-Score: 6.4/10

Publication date: February 3, 2026

Author: Analystock.ai

๐Ÿ“‹ Highlights

Segment Performance

The company's non-COVID product portfolio performed well, driven by products such as Abrysvo, Eliquis, Prevnar, and the Vyndaqel family. The company's COVID-19 products saw a significant decline, with revenues decreasing by approximately 40% operationally year-over-year. Dave Denton, CFO, noted that the company's refined commercial strategy was effective, driven by these key products.

Pipeline Progress

Pfizer made significant progress in its pipeline, with 40 approvals and critical readouts, and the initiation of 11 pivotal studies. The company's obesity portfolio saw a major advancement with the VSPR three study results, demonstrating robust weight loss with its investigational next-generation injectable GLP-1 receptor agonist, PF-3944. Chris Boshoff, Chief Scientific Officer, highlighted the potential of this platform, stating that the results "provide a compelling validation of our unique proprietary ultra-long-acting peptide platform."

Valuation

Using Pfizer's current valuation metrics, we can assess what's priced in. The company's P/E Ratio is 14.92, and the Dividend Yield is 6.67%. With an ROE of 10.91%, the company is generating strong returns on equity. Analysts estimate next year's revenue growth at -3.3%, which may impact the company's valuation. However, with a robust pipeline and a strong non-COVID product portfolio, Pfizer is well-positioned for long-term growth.

Outlook

Pfizer expects total company full-year 2026 revenues to be in the range of $59.5 billion to $62.5 billion and adjusted diluted earnings per share to be in the range of $2.80 to $3.00 per share. The company is focused on investing in key assets, managing upcoming LOEs, and driving growth through its advancing R&D pipeline and business development initiatives. With a strong financial performance and a promising pipeline, Pfizer is poised for continued success.

Pfizer's A-Score