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1. Company Snapshot

1.a. Company Description

Centessa Pharmaceuticals plc, a clinical-stage pharmaceutical company, discovers, develops, and delivers medicines to patients.Its registrational pipeline products include Lixivaptan, a vasopressin V2 receptor small molecule inhibitor that is in Phase III clinical development for the treatment of autosomal dominant polycystic kidney disease; and SerpinPC, an activated protein C inhibitor, which is in Phase IIa clinical development for the treatment of hemophilia A and B.The company also has emerging pipeline products under clinical proof of concept stage comprising LB101, a PD-L1xCD47 LockBody, as well as LB201, a PD-L1xCD3 LockBody, which are designed to selectively drive potent CD47 and CD3 effector function activity while avoiding systemic toxicity; ZF874, a small molecule pharmacological chaperone folding corrector of the Z variant of alpha-1-antitrypsin in Phase I clinical development for the treatment of alpha-1-antitrypsin deficiency; MGX292, a recombinant modified BMP9 replacement protein designed to overcome the deficiency in BMP9 signaling in Pulmonary Arterial Hypertension; and OX2R Agonists that are oral and intranasal selective orexin receptor 2 agonists designed to leverage structural insights and to directly target the underlying pathophysiology of orexin neuron loss in Narcolepsy Type 1.


In addition, the company has exploratory pipeline products under clinical proof of concept stage containing CBS001, an anti-LIGHT antibody, which preferentially binds the inflammatory membrane form of LIGHT in inflammatory/fibrotic diseases; and CBS004, a humanized mAb specific to BDCA2, expressed exclusively on plasmacytoid dendritic cells in systemic sclerosis, systemic lupus erythematosus, and other autoimmune diseases.Centessa Pharmaceuticals plc was incorporated in 2020 and is based in Altrincham, the United Kingdom.

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1.b. Last Insights on CNTA

Negative drivers behind Centessa Pharmaceuticals' recent performance include the company's escalating research and development expenses, which increased by 25% year-over-year, partly due to the ongoing Phase 2a clinical trial of ORX750. Additionally, the company's net loss widened to $43.8 million in Q4 2024, compared to a net loss of $31.1 million in the same period last year. Furthermore, the company's cash and cash equivalents decreased to $143.8 million as of December 31, 2024, from $173.8 million as of December 31, 2023, indicating a decline in liquidity.

1.c. Company Highlights

2. Transcript Summary

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3. NewsRoom

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What One Fund's Sale of Centessa Stock Signals About the Fast-Rising Biotech Company

Nov -29

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Campbell & CO Investment Adviser LLC Acquires New Position in Centessa Pharmaceuticals PLC Sponsored ADR $CNTA

Nov -18

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Centessa Stock Has Surged 77% Over the Past Year — But a Top Biotech Fund Is Still Buying

Nov -17

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Why Centessa Pharmaceuticals Stock Crushed the Market Today

Nov -12

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Centessa Pharmaceuticals Announces Pricing of $250,000,000 Public Offering of American Depositary Shares

Nov -12

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Centessa Pharmaceuticals Announces Proposed Public Offering of American Depositary Shares

Nov -11

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Centessa Pharmaceuticals to Participate in Upcoming Investor Conferences

Nov -07

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46,665 Shares in Centessa Pharmaceuticals PLC Sponsored ADR $CNTA Purchased by Y Intercept Hong Kong Ltd

Nov -06

4. Business Breakdown

4.a. Revenues by Country

4.b. Revenues by Segment

5. Expected revenues mid-term growth (9.27%)

6. Segments

Pharmaceutical

Expected Growth: 9.27%

Centessa Pharmaceuticals plc's 9.27% growth is driven by increasing demand for rare disease treatments, strategic partnerships, and a strong pipeline of novel therapies. The company's focus on gene therapy and small molecule development also contributes to its growth, as well as its ability to leverage its platform to identify and acquire promising assets.

7. Detailed Products

CX-102

CX-102 is a novel, oral, small molecule inhibitor of serine/threonine kinase 1 (STK11) for the treatment of solid tumors.

CX-202

CX-202 is a novel, oral, small molecule inhibitor of cyclin-dependent kinase 2/4/6 (CDK2/4/6) for the treatment of breast cancer and other solid tumors.

CX-205

CX-205 is a novel, oral, small molecule inhibitor of fibroblast growth factor receptor 1-3 (FGFR1-3) for the treatment of solid tumors.

CX-611

CX-611 is a novel, oral, small molecule inhibitor of bromodomain and extra-terminal motif (BET) for the treatment of hematological malignancies.

8. Centessa Pharmaceuticals plc's Porter Forces

Forces Ranking

Threat Of Substitutes

Centessa Pharmaceuticals plc has a moderate threat of substitutes due to the availability of alternative treatments and therapies for the diseases it targets.

Bargaining Power Of Customers

Centessa Pharmaceuticals plc has a low bargaining power of customers due to the specialized nature of its products and the lack of alternative options for patients.

Bargaining Power Of Suppliers

Centessa Pharmaceuticals plc has a moderate bargaining power of suppliers due to the availability of multiple suppliers for raw materials and the company's dependence on a few key suppliers.

Threat Of New Entrants

Centessa Pharmaceuticals plc has a high threat of new entrants due to the growing demand for pharmaceuticals and the increasing number of biotech startups entering the market.

Intensity Of Rivalry

Centessa Pharmaceuticals plc operates in a highly competitive industry with many established players, leading to a high intensity of rivalry.

9. SWOT Analysis

10. Capital Structure

10.a. Balance Sheet

10.b. Weighted Average Cost of capital

Value
Debt Weight 24.27%
Debt Cost 11.19%
Equity Weight 75.73%
Equity Cost 11.19%
WACC 11.19%
Leverage 32.04%

11. Quality Control: Centessa Pharmaceuticals plc passed 3 out of 9 key points

12.a Historical Valuation

12.b Price/Earnings Ratio

12.c Margin Valuation

12.d Peers Valuation

Peers Group Analysis

Stock-Card
Idorsia

A-Score: 5.1/10

Value: 8.4

Growth: 6.8

Quality: 5.2

Yield: 0.0

Momentum: 10.0

Volatility: 0.0

1-Year Total Return ->

Stock-Card
Centessa Pharmaceuticals

A-Score: 3.9/10

Value: 6.0

Growth: 3.9

Quality: 4.7

Yield: 0.0

Momentum: 8.0

Volatility: 0.7

1-Year Total Return ->

Stock-Card
NewAmsterdam Pharma

A-Score: 3.2/10

Value: 6.2

Growth: 4.0

Quality: 4.3

Yield: 0.0

Momentum: 4.5

Volatility: 0.3

1-Year Total Return ->

Stock-Card
Calliditas Therapeutics

A-Score: 3.0/10

Value: 6.0

Growth: 4.2

Quality: 3.8

Yield: 0.0

Momentum: 4.0

Volatility: 0.0

1-Year Total Return ->

Stock-Card
Atrys Health

A-Score: 2.7/10

Value: 6.0

Growth: 3.7

Quality: 1.9

Yield: 0.0

Momentum: 1.0

Volatility: 3.3

1-Year Total Return ->

Stock-Card
Formycon

A-Score: 2.2/10

Value: 6.0

Growth: 2.2

Quality: 3.4

Yield: 0.0

Momentum: 0.0

Volatility: 1.3

1-Year Total Return ->

Peers Metrics

12.e Scoring Insights

12.f DCF BETA

Parameters

Short Term Growth

Short term Time

Long-Term Growth

WACC

Target Price

29.91$

Current Price

29.91$

Potential

-0.00%

Expected Cash-Flows