Download PDF

1. Company Snapshot

1.a. Company Description

Alpine Immune Sciences, Inc., a clinical-stage biopharmaceutical company, focuses on the discovery and development of protein-based immunotherapies for the treatment of cancer, autoimmune/inflammatory disorders, and other diseases.Its product pipeline includes ALPN-101, an inducible T cell costimulator (ICOS)/cluster of differentiation 28 (CD28) antagonist program for the treatment of autoimmune and inflammatory diseases; ALPN-202, a conditional CD28 costimulator and dual checkpoint inhibitor for the treatment of cancer; and ALPN-303, a dual B cell cytokine antagonist for the treatment of B cell-mediated inflammatory and autoimmune diseases.The company has a collaboration agreement with AbbVie Ireland Unlimited Company for the development of ALPN-101; and Adaptimmune Therapeutics plc to develop next-generation SPEAR T cell products.


Alpine Immune Sciences, Inc.was incorporated in 2007 and is headquartered in Seattle, Washington.

Show Full description

1.b. Last Insights on ALPN

Alpine Immune Sciences, Inc. (ALPN) experienced a 56.0% performance over the past 3 months, driven by a $4.9 billion buyout offer from Vertex Pharmaceuticals (VRTX) after receiving positive news on its autoimmune drug Povetacicept. The acquisition is expected to bolster Vertex's rare-disease franchise, and the deal's value is likely to be reflected in the company's stock performance.

1.c. Company Highlights

2. Transcript Summary

Unfortunately this company is not part of our coverage yet. But as part of your subscription plan you can request it by clicking just below and we'll process.

3. NewsRoom

Card image cap

Earnings Preview: Alpine Immune Sciences, Inc. (ALPN) Q1 Earnings Expected to Decline

May -02

Card image cap

ALPINE IMMUNE INVESTOR ALERT by the Former Attorney General of Louisiana: Kahn Swick & Foti, LLC Investigates Adequacy of Price and Process in Proposed Sale of Alpine Immune Sciences, Inc. - ALPN

Apr -26

Card image cap

SHAREHOLDER INVESTIGATION: The M&A Class Action Firm Announces an Investigation of Encore Wire Corporation - WIRE

Apr -17

Card image cap

Can You Afford to Ignore These 3 Biotech Stocks Up Over 160% in 2024?

Apr -15

Card image cap

Could This Stock Be the Next Biotech Buyout?

Apr -13

Card image cap

Alpine (ALPN) Surges 37% on $4.9B Buyout Offer From Vertex

Apr -12

Card image cap

2 Biotech Stocks Driving the Nasdaq Today

Apr -11

Card image cap

Vertex Pharmaceuticals to Buy Alpine Immune in $4.9B Deal

Apr -11

4. Business Breakdown

4.a. Revenues by Country

4.b. Revenues by Segment

5. Expected revenues mid-term growth (11.30%)

6. Segments

Protein-based Immunotherapies

Expected Growth: 11.3%

Alpine Immune Sciences' 11.3% growth in Protein-based Immunotherapies is driven by increasing adoption in cancer treatment, rising demand for personalized medicine, and advancements in gene editing technologies like CRISPR. Additionally, strategic partnerships and collaborations are expanding the company's pipeline and accelerating clinical trials, further fueling growth.

7. Detailed Products

ALPN-101

A dual-acting fusion protein designed to block CD28 and CD80/86, which are key targets for autoimmune disease treatment.

ALPN-202

A variant of the CD28 receptor that selectively binds to CD80/86, blocking the co-stimulatory signal and reducing T cell activation.

Transmembrane Immunomodulatory Proteins (TIPs)

A novel class of immunomodulatory proteins that can be engineered to target specific immune cells and modulate their activity.

Variant Ig Domain (vIgD)

A novel class of immunomodulatory proteins that can be engineered to target specific immune cells and modulate their activity.

8. Alpine Immune Sciences, Inc.'s Porter Forces

Forces Ranking

Threat Of Substitutes

Alpine Immune Sciences, Inc. has a low threat of substitutes due to its unique and patented technology in the development of novel protein-based immunotherapies.

Bargaining Power Of Customers

Alpine Immune Sciences, Inc. has a medium bargaining power of customers due to the presence of a few large pharmaceutical companies that can influence the market.

Bargaining Power Of Suppliers

Alpine Immune Sciences, Inc. has a low bargaining power of suppliers due to its reliance on a few key suppliers for raw materials and equipment.

Threat Of New Entrants

Alpine Immune Sciences, Inc. has a high threat of new entrants due to the growing interest in immunotherapy and the increasing number of biotech startups.

Intensity Of Rivalry

Alpine Immune Sciences, Inc. operates in a moderately competitive industry with a few established players, leading to a medium intensity of rivalry.

9. SWOT Analysis

10. Capital Structure

10.a. Balance Sheet

10.b. Weighted Average Cost of capital

Value
Debt Weight 2.93%
Debt Cost 3.95%
Equity Weight 97.07%
Equity Cost 8.79%
WACC 8.65%
Leverage 3.02%

11. Quality Control: Alpine Immune Sciences, Inc. passed 4 out of 9 key points

12.a Historical Valuation

12.b Price/Earnings Ratio

12.c Margin Valuation

12.d Peers Valuation

Peers Group Analysis

Stock-Card
Corcept Therapeutics

A-Score: 4.8/10

Value: 0.3

Growth: 8.0

Quality: 8.8

Yield: 0.0

Momentum: 10.0

Volatility: 1.7

1-Year Total Return ->

Stock-Card
Insmed

A-Score: 4.3/10

Value: 6.0

Growth: 3.3

Quality: 4.1

Yield: 0.0

Momentum: 10.0

Volatility: 2.7

1-Year Total Return ->

Stock-Card
ADMA Biologics

A-Score: 4.2/10

Value: 1.5

Growth: 8.4

Quality: 8.5

Yield: 0.0

Momentum: 3.0

Volatility: 4.0

1-Year Total Return ->

Stock-Card
Novavax

A-Score: 3.9/10

Value: 7.1

Growth: 5.4

Quality: 7.2

Yield: 0.0

Momentum: 2.5

Volatility: 1.3

1-Year Total Return ->

Stock-Card
Arcellx

A-Score: 3.9/10

Value: 6.0

Growth: 5.7

Quality: 5.0

Yield: 0.0

Momentum: 3.0

Volatility: 4.0

1-Year Total Return ->

Stock-Card
Alpine Immune Sciences

A-Score: 3.8/10

Value: 6.0

Growth: 6.6

Quality: 4.0

Yield: 0.0

Momentum: 5.0

Volatility: 1.0

1-Year Total Return ->

Peers Metrics

12.e Scoring Insights

12.f DCF BETA

Parameters

Short Term Growth

Short term Time

Long-Term Growth

WACC

Target Price

64.97$

Current Price

64.97$

Potential

-0.00%

Expected Cash-Flows