Download PDF

1. Company Snapshot

1.a. Company Description

Phathom Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company, focuses on developing and commercializing treatments for gastrointestinal diseases.The company has the rights in the United States, Europe, and Canada to vonoprazan, a potassium-competitive acid blocker (P-CAB) that blocks acid secretion in the stomach.It is also developing vonoprazan, which is in Phase III clinical trials for the treatment of erosive gastroesophageal reflux disease; and in combination with antibiotics for the treatment of Helicobacter pylori infection.


Phathom Pharmaceuticals, Inc.was incorporated in 2018 and is headquartered in Florham Park, New Jersey.

Show Full description

1.b. Last Insights on PHAT

Phathom Pharmaceuticals' recent performance was driven by several positive factors. The company's VOQUEZNA launch momentum continues, with over 390,000 prescriptions filled to date, written by more than 23,600 healthcare providers. This strong adoption rate is a testament to the product's effectiveness in treating gastrointestinal diseases. Additionally, the company's net revenues of $28.5 million reported for Q1 2025 exceeded expectations. Furthermore, Phathom Pharmaceuticals has implemented strategic cost reductions and executive leadership changes to support sustainable revenue growth and achieve profit from operations, excluding stock-based compensation, in 2026. The company's recent FDA decision to recognize 10 years of regulatory exclusivity for VOQUEZNA through May 3, 2032, also provides a significant boost to the company's prospects.

1.c. Company Highlights

2. Phathom Pharmaceuticals' Q3 Earnings: A Strong Beat with 25% Revenue Growth

Phathom Pharmaceuticals reported a strong third quarter with net revenue reaching $49.5 million, a 25% quarter-over-quarter growth, beating expectations. The company's cash operating expenses were $49.3 million, a 43% decrease from the previous quarter and a 50% decrease from Q1 2025. The actual EPS came out at '-0.15', relative to estimates at '-0.3', showcasing a significant improvement. With a current cash balance of approximately $135 million, Phathom believes it can support operations through 2026 without additional equity financing.

Publication Date: Nov -17

📋 Highlights
  • Revenue Growth Surpasses Expectations: Q3 net revenue surged 25% QoQ to $49.5 million, exceeding forecasts.
  • Operating Expenses Decline Sharply: Cash operating expenses fell 43% QoQ ($49.3M) and 50% from Q1 2025, reducing cash usage by 77% from Q2.
  • Prescription Momentum Accelerates: Q3 filled prescriptions hit 221,000 (144,000 covered), a 23% QoQ growth, with 36% growth in total prescriptions since Q2.
  • Strategic Shift to Gastroenterology: 70% of sales force now targets GI specialists, driving focus on repeat prescribing and depth over breadth.
  • Exclusivity and Profitability Outlook: Orange Book exclusivity extended to 2033; cash balance ($135M) supports operations through 2026, with operating profitability targeted in 2026.

Revenue Growth and Prescription Trends

The company's launch-to-date filled prescriptions have reached 790,000, with a 36% growth since the Q2 call. In Q3, there were 221,000 filled prescriptions, with 144,000 covered scripts growing 23% quarter-over-quarter. Phathom has shifted its sales focus to gastroenterology, with 70% of its sales force time now spent in gastroenterology practices. The company is tracking metrics on repeat prescribing behavior and seeing evidence of growth in utilization and more physicians becoming regular prescribers.

Operating Expenses and Path to Profitability

For Q4, operating expenses are expected to be higher due to the EoE Phase II trial but are expected to be below $55 million. Phathom refined its full-year 2025 non-GAAP operating expenses to $280 million to $290 million and believes it is on a path towards operating profitability in 2026. The company aims to achieve an operating profit position next year, with a cash usage of $14 million this quarter. Analysts estimate next year's revenue growth at 82.7%, indicating a significant increase in top-line growth.

Valuation and Growth Prospects

With a P/S Ratio of 7.04, the market is pricing in significant revenue growth for Phathom Pharmaceuticals. The company's ROE is 77.32%, indicating a strong return on equity. However, the EV/EBITDA ratio is -4.44, suggesting that the company's earnings before interest, taxes, depreciation, and amortization are not yet positive. As Phathom continues to grow its revenue and move towards operating profitability, the valuation metrics will be closely watched to assess the stock's potential.

Commercial Strategy and Patient Access

Phathom is working to improve patient access to its product through the Blink service, which offers a $25 co-pay for covered prescriptions and a $50 cash price for uncovered ones. This approach enables the company to minimize prescription abandonment and patient out-of-pocket costs. By educating physicians about Blink's advantages, Phathom can manage the cycle to reduce co-pay costs and increase access to its products.

3. NewsRoom

Card image cap

Phathom Pharmaceuticals: Superior Efficacy Drives Vonoprazan Growth

Nov -21

Card image cap

Phathom Pharmaceuticals, Inc. (NASDAQ:PHAT) Receives Average Recommendation of “Moderate Buy” from Analysts

Nov -15

Card image cap

Phathom Pharmaceuticals Announces First Patient Dosed in Phase 2 Study of VOQUEZNA® (vonoprazan) in Eosinophilic Esophagitis (EoE)

Nov -04

Card image cap

Phathom Pharmaceuticals to Participate in Upcoming Investor Conferences

Nov -03

Card image cap

Phathom Pharmaceuticals, Inc. (PHAT) Q3 2025 Earnings Call Transcript

Oct -30

Card image cap

Phathom Pharmaceuticals, Inc. (PHAT) Reports Q3 Loss, Tops Revenue Estimates

Oct -30

Card image cap

Phathom Pharmaceuticals Reports Third Quarter 2025 Financial Results and Provides Business Update

Oct -30

Card image cap

Phathom Pharmaceuticals Announces Publication of Data from Phase 3 pHalcon-NERD-301 Study Showing VOQUEZNA® (vonoprazan) Improved Nocturnal GERD Symptoms in Patients with Non-Erosive Reflux Disease

Oct -25

4. Business Breakdown

4.a. Revenues by Country

4.b. Revenues by Segment

5. Expected revenues mid-term growth (8.50%)

6. Segments

Vonoprazan

Expected Growth: 8.5%

Vonoprazan's 8.5% growth is driven by increasing adoption in gastroesophageal reflux disease (GERD) treatment, expanding label indications, and growing demand for proton pump inhibitor (PPI) alternatives. Additionally, Phathom's strategic partnerships, strong marketing efforts, and favorable reimbursement landscape contribute to the drug's rapid growth.

7. Detailed Products

Sonalleve

A non-invasive, ultrasound-based treatment for uterine fibroids

TheraSphere

A yttrium-90 (Y-90) glass microsphere for the treatment of liver cancer

SIR-Spheres

A yttrium-90 (Y-90) resin microsphere for the treatment of liver cancer

Quadramet

A radiopharmaceutical for the treatment of bone metastases

8. Phathom Pharmaceuticals, Inc.'s Porter Forces

Forces Ranking

Threat Of Substitutes

Phathom Pharmaceuticals, Inc. has a moderate threat of substitutes due to the presence of alternative treatments and therapies for gastrointestinal diseases.

Bargaining Power Of Customers

Phathom Pharmaceuticals, Inc. has a low bargaining power of customers due to the lack of negotiating power among individual patients and the complexity of the pharmaceutical supply chain.

Bargaining Power Of Suppliers

Phathom Pharmaceuticals, Inc. has a moderate bargaining power of suppliers due to the presence of multiple suppliers for raw materials and the company's dependence on these suppliers.

Threat Of New Entrants

Phathom Pharmaceuticals, Inc. has a high threat of new entrants due to the growing demand for gastrointestinal treatments and the increasing number of biotech startups entering the market.

Intensity Of Rivalry

Phathom Pharmaceuticals, Inc. operates in a highly competitive market with several established players, leading to a high intensity of rivalry among competitors.

9. SWOT Analysis

10. Capital Structure

10.a. Balance Sheet

10.b. Weighted Average Cost of capital

Value
Debt Weight 209.79%
Debt Cost 7.27%
Equity Weight -109.79%
Equity Cost 7.27%
WACC 7.27%
Leverage -191.08%

11. Quality Control: Phathom Pharmaceuticals, Inc. passed 4 out of 9 key points

12.a Historical Valuation

12.b Price/Earnings Ratio

12.c Margin Valuation

12.d Peers Valuation

Peers Group Analysis

Stock-Card
Fortress Biotech

A-Score: 4.5/10

Value: 8.4

Growth: 5.3

Quality: 3.9

Yield: 0.0

Momentum: 8.5

Volatility: 1.0

1-Year Total Return ->

Stock-Card
Adaptive Biotechnologies

A-Score: 4.4/10

Value: 6.0

Growth: 3.8

Quality: 4.7

Yield: 0.0

Momentum: 10.0

Volatility: 1.7

1-Year Total Return ->

Stock-Card
Tonix Pharmaceuticals

A-Score: 4.2/10

Value: 7.6

Growth: 5.2

Quality: 3.8

Yield: 0.0

Momentum: 8.5

Volatility: 0.3

1-Year Total Return ->

Stock-Card
AnaptysBio

A-Score: 4.1/10

Value: 8.2

Growth: 3.2

Quality: 5.0

Yield: 0.0

Momentum: 6.5

Volatility: 1.7

1-Year Total Return ->

Stock-Card
Phathom Pharmaceuticals

A-Score: 3.4/10

Value: 8.2

Growth: 4.4

Quality: 6.0

Yield: 0.0

Momentum: 1.5

Volatility: 0.0

1-Year Total Return ->

Stock-Card
REGENXBIO

A-Score: 3.1/10

Value: 7.0

Growth: 2.2

Quality: 3.9

Yield: 0.0

Momentum: 4.0

Volatility: 1.3

1-Year Total Return ->

Peers Metrics

12.e Scoring Insights

12.f DCF BETA

Parameters

Short Term Growth

Short term Time

Long-Term Growth

WACC

Target Price

14.58$

Current Price

14.58$

Potential

-0.00%

Expected Cash-Flows