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1. Company Snapshot

1.a. Company Description

Senti Biosciences, Inc.operates as a gene circuit company.The company develops cell and gene therapies engineered with gene circuits that are designed to reprogram cells with biological logic to sense inputs, compute decisions, and respond to respective cellular environments.


Its synthetic biology platform utilizes off-the-shelf chimeric antigen receptor natural killer (CAR-NK) cells to target particularly challenging liquid and solid tumor oncology indications.The company's lead programs include SENTI-202, a Logic Gated OR+NOT off-the-shelf CAR-NK cell therapy designed to target and eliminate acute myeloid leukemia (AML) cells, while sparing the healthy bone marrow; and SENTI-301, a multi-armed off-the-shelf CAR-NK cell therapy designed for the treatment of hepatocellular carcinoma (HCC).It also develops SENTI-401, a Logic Gated (NOT) off-the-shelf CAR-NK cell therapy designed to target and eliminate colorectal cancer (CRC) cells, while sparing healthy cells in the body.


The company was founded in 2016 and is based in South San Francisco, California.

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1.b. Last Insights on SNTI

The recent 3-month performance of Senti Biosciences, Inc. has been negatively impacted by ongoing investigations into the fairness of its acquisition by Dynamics Special Purpose Co. in June 2022. Multiple law firms, including Levi & Korsinsky, LLP, have initiated investigations into the matter, citing potential harm to stockholders and inadequate disclosure of material facts. This scrutiny has likely contributed to the company's recent challenges.

1.c. Company Highlights

2. Transcript Summary

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3. NewsRoom

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Senti Bio to Host Conference Call and Webcast to Discuss SENTI-202 Clinical Data Being Presented at the American Society of Hematology (ASH) Annual Meeting 2025 on Tuesday, December 9th at 8:00 AM ET

Dec -04

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Senti Bio Reports Third Quarter 2025 Financial Results and Confirms Next Clinical Data Readout for Phase 1 SENTI-202 Study in Acute Myeloid Leukemia (AML) at the American Society of Hematology Annual Meeting in December

Nov -13

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Senti Bio to Present Updated Clinical Results of First-in-Class Logic Gated CD33/FLT3 Cell Therapy, SENTI-202, at the American Society of Hematology (ASH) Annual Meeting 2025

Nov -03

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Senti Bio to Present at Chardan's 9th Annual Genetic Medicines Conference

Oct -16

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Senti Bio to Present at BioJapan

Oct -06

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Senti Bio to Present at the MedInvest Biotech & Pharma Conference

Sep -18

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Senti Bio to Present at the H.C. Wainwright 27th Annual Global Investment Conference

Sep -02

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Senti Biosciences to Present at the Webull Financial Corporate Connect Webinar Series: Biotech/MedTech

Aug -14

4. Business Breakdown

4.a. Revenues by Country

4.b. Revenues by Segment

5. Expected revenues mid-term growth (3.00%)

6. Segments

Next-generation Cell and Gene Therapies

Expected Growth: 3.0%

Senti Biosciences' next-generation cell and gene therapies are driven by increasing demand for personalized medicine, advancements in gene editing technologies like CRISPR, and growing investments in regenerative medicine. Additionally, the company's proprietary gene circuit technology and strong partnerships with pharmaceutical companies contribute to its 3.0 growth rate.

7. Detailed Products

Gene Circuit Engineering

A suite of tools and services for the design, construction, and optimization of gene circuits for various applications

Cancer Treatment

Personalized cancer therapies using gene circuits to selectively kill cancer cells

Gene Regulation Therapies

Gene circuits for the regulation of gene expression to treat genetic disorders

Synthetic Biology Tools

A platform for the design, construction, and testing of genetic circuits

Cell Therapy

Gene-modified cells for the treatment of various diseases, including cancer and genetic disorders

8. Senti Biosciences, Inc.'s Porter Forces

Forces Ranking

Threat Of Substitutes

Senti Biosciences, Inc. operates in a niche market with limited substitutes, but the threat of substitutes is still present due to the evolving nature of the biotechnology industry.

Bargaining Power Of Customers

Senti Biosciences, Inc. has a diverse customer base, which reduces the bargaining power of individual customers. Additionally, the company's products are highly specialized, making it difficult for customers to switch to alternative suppliers.

Bargaining Power Of Suppliers

Senti Biosciences, Inc. relies on a few key suppliers for critical components, which gives these suppliers some bargaining power. However, the company's strong relationships with its suppliers and its ability to negotiate contracts mitigate this risk.

Threat Of New Entrants

The biotechnology industry has high barriers to entry, including significant capital requirements, complex regulatory requirements, and the need for specialized expertise. These barriers make it difficult for new entrants to compete with established companies like Senti Biosciences, Inc.

Intensity Of Rivalry

The biotechnology industry is highly competitive, with many established companies competing for market share. Senti Biosciences, Inc. faces intense competition from companies with similar products and technologies, which can lead to pricing pressure and reduced market share.

9. SWOT Analysis

10. Capital Structure

10.a. Balance Sheet

10.b. Weighted Average Cost of capital

Value
Debt Weight 36.02%
Debt Cost 3.95%
Equity Weight 63.98%
Equity Cost 18.35%
WACC 13.16%
Leverage 56.29%

11. Quality Control: Senti Biosciences, Inc. passed 3 out of 9 key points

12.a Historical Valuation

12.b Price/Earnings Ratio

12.c Margin Valuation

12.d Peers Valuation

Peers Group Analysis

Stock-Card
Atara Bio

A-Score: 5.6/10

Value: 7.4

Growth: 8.0

Quality: 7.0

Yield: 0.0

Momentum: 10.0

Volatility: 1.0

1-Year Total Return ->

Stock-Card
Eton Pharmaceuticals

A-Score: 4.4/10

Value: 2.2

Growth: 7.1

Quality: 4.6

Yield: 0.0

Momentum: 10.0

Volatility: 2.7

1-Year Total Return ->

Stock-Card
Century Therapeutics

A-Score: 3.8/10

Value: 9.6

Growth: 5.4

Quality: 5.2

Yield: 0.0

Momentum: 0.5

Volatility: 2.0

1-Year Total Return ->

Stock-Card
Marinus Pharmaceuticals

A-Score: 3.7/10

Value: 9.0

Growth: 6.2

Quality: 6.1

Yield: 0.0

Momentum: 0.0

Volatility: 1.0

1-Year Total Return ->

Stock-Card
Biora Therapeutics

A-Score: 3.0/10

Value: 8.8

Growth: 3.4

Quality: 5.2

Yield: 0.0

Momentum: 0.0

Volatility: 0.3

1-Year Total Return ->

Stock-Card
Senti Biosciences

A-Score: 2.5/10

Value: 7.0

Growth: 2.9

Quality: 2.9

Yield: 0.0

Momentum: 2.0

Volatility: 0.3

1-Year Total Return ->

Peers Metrics

12.e Scoring Insights

12.f DCF BETA

Parameters

Short Term Growth

Short term Time

Long-Term Growth

WACC

Target Price

2.13$

Current Price

2.13$

Potential

-0.00%

Expected Cash-Flows