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1. Company Snapshot

1.a. Company Description

SpringWorks Therapeutics, Inc.acquires, develops, and commercializes medicines for underserved patient populations suffering from rare diseases and cancer.Its lead product candidate is nirogacestat, an oral small molecule gamma secretase inhibitor that is in Phase III clinical trial for the treatment of desmoid tumors.


The company is also developing mirdametinib, an oral small molecule MEK inhibitor that is in Phase 2b clinical trials for the treatment of neurofibromatosis type 1-associated plexiform neurofibromas, as well as Phase 1/2a clinical trial for the treatment of NF1-PN; mirdametinib + lifirafenib, a combination therapy that is in Phase 1b/2 clinical trial in patients with advanced or refractory solid tumors; and mirdametinib in monotherapy and combination approaches to treat solid tumors.In addition, it develops BGB-3245, an oral selective small molecule inhibitor of monomeric and dimeric forms of activating BRAF mutations, which is in Phase I clinical trial.The company has collaborations with BeiGene, Ltd., GlaxoSmithKline LLC, and Allogene to develop combination approaches with nirogacestat and mirdametinib; and license agreements with Pfizer Inc.


for nirogacestat and mirdametinib.It also has a license agreement with Katholieke Universiteit Leuven and the Flanders Institute for Biotechnology for a portfolio of novel small molecule inhibitors of the TEA Domain; and Dana-Farber Cancer Institute for a portfolio of novel small molecule inhibitors of Epidermal Growth Factor Receptor.In addition, the company has clinical collaboration agreement with Janssen Biotech, Inc., Precision BioSciences, Inc., Seagen Inc., and AbbVie, Inc.


SpringWorks Therapeutics, Inc.was founded in 2017 and is headquartered in Stamford, Connecticut.

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1.b. Last Insights on SWTX

SpringWorks Therapeutics' recent performance was driven by the European Commission's approval of OGSIVEO (nirogacestat) for the treatment of adults with desmoid tumors, marking the first and only therapy to receive marketing authorization in the EU for this indication. Additionally, the company's acquisition by Merck KGaA for $3.4 billion in July 2025 provided a significant boost, as the deal is expected to accelerate sustainable growth in Merck's healthcare business. Furthermore, Immunome's lead asset, varegacestat, shows promising efficacy in desmoid tumors, with phase 3 topline data expected by the end of 2025, potentially enabling accelerated approval.

1.c. Company Highlights

2. Transcript Summary

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3. NewsRoom

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SpringWorks Therapeutics Announces Publication of Long-Term Efficacy and Safety Data from the Phase 3 DeFi Trial of OGSIVEO® (nirogacestat) in Adults with Desmoid Tumors in the Journal of Clinical Oncology

Oct -21

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SpringWorks Therapeutics Announces Publication of Long-Term Efficacy and Safety Data from the Phase 3 DeFi Trial of OGSIVEO® (nirogacestat) in Adults with Desmoid Tumors in the Journal of Clinical Oncology

Oct -21

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European Commission Grants Approval of OGSIVEO® (nirogacestat) for the Treatment of Adults with Desmoid Tumors

Aug -18

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Immunome: SpringWorks Buyout Informs The Potential Upside Here

Aug -12

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European Commission Grants Conditional Approval of EZMEKLY® (mirdametinib) for the Treatment of Adult and Pediatric Patients with NF1-PN

Jul -18

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Merck KGaA, Darmstadt, Germany Completes Acquisition of SpringWorks Therapeutics to Accelerate Sustainable Growth of its Healthcare Business

Jul -01

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SpringWorks Therapeutics Receives Positive CHMP Opinion for Nirogacestat for the Treatment of Adults with Desmoid Tumors

Jun -20

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SpringWorks Gets CHMP Nod for Mirdametinib in Rare Disease

May -26

4. Business Breakdown

4.a. Revenues by Country

4.b. Revenues by Segment

5. Expected revenues mid-term growth (10.47%)

6. Segments

Life-changing Medicines

Expected Growth: 10.47%

SpringWorks Therapeutics' life-changing medicines drive 10.47% growth, fueled by increasing demand for rare disease treatments, strategic partnerships, and a strong pipeline of novel therapies. Additionally, advancements in gene therapy and precision medicine contribute to the company's rapid expansion.

7. Detailed Products

Naxitamab

A monoclonal antibody targeting GD2 for the treatment of neuroblastoma and osteosarcoma

Margetuximab

A monoclonal antibody targeting HER2 for the treatment of breast cancer

SpringWorks-1

A small molecule inhibitor of the B-cell lymphoma 2 (BCL-2) protein for the treatment of hematological malignancies

SpringWorks-2

A small molecule inhibitor of the mitogen-activated protein kinase (MAPK) pathway for the treatment of solid tumors

8. SpringWorks Therapeutics, Inc.'s Porter Forces

Forces Ranking

Threat Of Substitutes

SpringWorks Therapeutics, Inc. has a moderate threat of substitutes due to the presence of alternative treatments and therapies for rare diseases and cancer.

Bargaining Power Of Customers

The bargaining power of customers is low due to the specialized nature of SpringWorks Therapeutics, Inc.'s products and the lack of alternative options for patients.

Bargaining Power Of Suppliers

The bargaining power of suppliers is moderate due to the presence of multiple suppliers for raw materials and the company's dependence on a few key suppliers.

Threat Of New Entrants

The threat of new entrants is high due to the growing interest in rare disease and cancer treatment, and the potential for new companies to enter the market.

Intensity Of Rivalry

The intensity of rivalry is high due to the presence of established companies and the increasing competition for market share in the rare disease and cancer treatment market.

9. SWOT Analysis

10. Capital Structure

10.a. Balance Sheet

10.b. Weighted Average Cost of capital

Value
Debt Weight 1.11%
Debt Cost 3.95%
Equity Weight 98.89%
Equity Cost 8.11%
WACC 8.07%
Leverage 1.13%

11. Quality Control: SpringWorks Therapeutics, Inc. passed 3 out of 9 key points

12.a Historical Valuation

12.b Price/Earnings Ratio

12.c Margin Valuation

12.d Peers Valuation

Peers Group Analysis

Stock-Card
SpringWorks Therapeutics

A-Score: 5.1/10

Value: 6.2

Growth: 4.4

Quality: 5.0

Yield: 0.0

Momentum: 9.5

Volatility: 5.3

1-Year Total Return ->

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Agios Pharmaceuticals

A-Score: 4.4/10

Value: 6.7

Growth: 4.1

Quality: 7.2

Yield: 0.0

Momentum: 4.0

Volatility: 4.3

1-Year Total Return ->

Stock-Card
Cytokinetics

A-Score: 3.5/10

Value: 8.0

Growth: 0.4

Quality: 4.9

Yield: 0.0

Momentum: 6.0

Volatility: 1.7

1-Year Total Return ->

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Sarepta Therapeutics

A-Score: 3.2/10

Value: 6.4

Growth: 7.9

Quality: 4.2

Yield: 0.0

Momentum: 0.0

Volatility: 1.0

1-Year Total Return ->

Stock-Card
Avidity Biosciences

A-Score: 3.2/10

Value: 6.2

Growth: 2.7

Quality: 5.1

Yield: 0.0

Momentum: 4.0

Volatility: 1.0

1-Year Total Return ->

Stock-Card
Crinetics Pharmaceuticals

A-Score: 2.5/10

Value: 6.4

Growth: 1.1

Quality: 3.9

Yield: 0.0

Momentum: 1.0

Volatility: 2.7

1-Year Total Return ->

Peers Metrics

12.e Scoring Insights

12.f DCF BETA

Parameters

Short Term Growth

Short term Time

Long-Term Growth

WACC

Target Price

46.99$

Current Price

46.99$

Potential

-0.00%

Expected Cash-Flows